Research field

Bioelectronics, nanobiotechnology, biosensors

Memberships

Japan Society for Applied Physics, Surface Science Society of Japan,
　Chemical Society of Japan, Japan Society for Analytical Chemistry,
　　American Chemical Society, Japanese Pharmacological Society

Ongoing projects

• Reconstitution and aplication of biological functions on chips
• Novel electronic devices based on biomolecules

Keywords

Artificial bilayer lipid membranes, nanostructures, neural signal transmission

Selected publications

• An electrically resistive sheet of glial cells for amplifying signals of neuronal extracellular recordings.
  R. Matsumura, H. Yamamoto, M. Niwano, and A. Hirano-Iwata
  Appl. Phys. Lett., 108, 023701 (2016).
• Reconstitution of human ether-a-go-go-related gene channels in microfabricated silicon chips.
  A. Oshima, A. Hirano-Iwata, H. Mozumi, Y. Ishinari, Y. Kimura, and M. Niwano
  Anal. Chem. 85, 4363-4369 (2013).
• Free-standing lipid bilayers in silicon chips—Membrane stabilization based on microfabricated apertures with a nanometer-scale smoothness.
  A. Hirano-Iwata, K. Aoto, A. Oshima, T. Taira, R. Yamaguchi, Y. Kimura, and M. Niwano
  Langmuir 26, 1949-1952 (2010).
• Label-free detection of protein-protein interactions at the GaAs/water interface through surface infrared spectroscopy: Discrimination between specific and nonspecific interactions by using secondary structure analysis.
  K. Onodera, A. Hirano-Iwata, K. Miyamoto, Y. Kimura, M. Kataoka, Y. Shinohara, and M. Niwano
  Langmuir 23, 12287-12292 (2007).
• A single-channel sensor based on gramicidin controlled by molecular recognition at bilayer lipid membranes containing receptor.
  A. Hirano, M. Wakabayashi, Y. Matsuno, and M. Sugawara
  Biosens. Bioelectron. 18, 973-983 (2003).