業 績


  • Model-free idealization: Adaptive integrated approach for idealization of ion-channel currents.
    M. Sato, M. Hariyama, M. Komiya, K. Suzuki, Y. Tozawa, H. Yamamoto, A. Hirano-Iwata
    Biophysical Journal 122, 1-17 (2023).
  • Two-dimensional water-molecule-cluster layers at nanobubble interfaces.
    M. Niwano, T. Ma, K. Iwata, D. Tadaki, H. Yamamoto, Y. Kimura, A. Hirano-Iwata
    Journal of Colloid and Interface Science 652, 1775-1783 (2023).
  • Modular architecture facilitates noise-driven control of synchrony in neuronal networks.
    H. Yamamoto, F.P. Spitzner, T. Takemuro, V.Buendía, H. Murota, C. Morante, T. Konno, S. Sato, A. Hirano-Iwata, A. Levina, V. Priesemann, M.A. Muñoz, J. Zierenberg, J. Soriano
    Science Advances 9, eade1755 (2023).
  • Microfluidic technologies for reconstituting neuronal network functions in vitro.
    H. Yamamoto, A. Hirano-Iwata, S. Sato
    JSAP Review 2023, 230420 (2023).
  • Biological neurons act as generalization filters in reservoir computing.
    T. Sumi, H. Yamamoto, Y. Katori, K. Ito, S. Moriya, T. Konno, S. Sato, A. Hirano-Iwata
    PNAS 120, 37307467 (2023).
  • マイクロ流体デバイスを用いた神経回路機能の実細胞再構成
    山本英明, 平野愛弓, 佐藤茂雄
    応用物理 92, 278-282 (2023).
  • Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks.
    Y. Sato, H. Yamamoto, H. Kato, T. Tanii, S. Sato, A. Hirano-Iwata
    Front. Neurosci. 16, 943310 (2023).


  • New Aspects of Bilayer Lipid Membranes for the Analysis of Ion Channel Functions.
    H. Kageyama, T. Ma, M. Sato, M. Komiya, D. Tadaki, A. Hirano-Iwata
    Membranes 12, 863 (2022).
  • Application of neural network based regression model to gas concentration analysis of TiO2 nanotube-type gas sensors.
    K. Iwata, H. Abe, T. Ma, D. Tadaki, A. Hirano-Iwata, Y. Kimura, S. Suda, M. Niwano
    Sensers and Actuators B: Chemical 361, 131732 (2022).
  • Lateral voltage as a new input for artificial lipid bilayer systems.
    T. Ma, M. Sato, M. Komiya, K. Kanomata, T. Watanabe, X. Feng, R. Miyata, D. Tadaki, F. Hirose, Y. Tozawa, A. Hirano-Iwata
    Faraday Discussions 233, 244-256 (2022).
  • Filtration‑processed biomass nanofiber electrodes for flexible bioelectronics.
    D. Ando, T. F. Teshima, F. Zurita, H. Peng, K. Ogura, K. Kondo, L. Weiβ, A. Hirano‑Iwata, M. Becherer, J. Alexander, B. Wolfrum
    J. Nanobiotechnol., 20, 491 (2022).


  • Bactericidal activity of bulk nanobubbles through active oxygen species generation.
    M. Yamaguchi, T. Ma, D. Tadaki, A. Hirano-Iwata, Y. Watanabe, H. Kanetaka, H. Fujimori, E. Takemoto, M. Niwano
    Langmuir 37, 9883-9891 (2021).
  • Selective stimulation of a target neuron in micropatterned neuronal circuits using a pair of needle electrodes.
    K. Hattori, H. Kurakake, J. Imai, T. Hashimoto, M. Ishida, K. Sato, H. Takahashi, S. Oguma, H. Yamamoto, A. Hirano-Iwata, T. Tanii
    Electrochemistry 89, 348-354 (2021).
  • Liposome manipulation using the evanescent field of an optical nanofiber.
    M. Sadgrove, A. Suda, R. Matsuyama, M. Komiya, T. Yoshino, D. Yamaura, M. Sugawara, M. Niwano, Y. Mitsumori, K. Edamatsu, A. Hirano-Iwata
    Optics InfoBase Conference Papers, OSA Technical Digest (Optica Publishing Group)paper AW4D.4 (2021).
  • Advances in artificial bilayer lipid membranes as a novel biosensing platform: From drug-screening to self-assembled devices.
    T. Ma, M. Sato, M. Komiya, X. Feng, D. Tadaki, A. Hirano-Iwata
    Chem. Lett. 50, 418–425 (2021).(Featured as Inside Cover)
  • Parallel Recordings of Transmembrane hERG Channel Currents Based on Solvent-Free Lipid Bilayer Microarray.
    R. Miyata, D. Tadaki, D. Yamaura, S. Araki, M. Sato, M. Komiya, T. Ma, H. Yamamoto, M. Niwano, A. Hirano-Iwata
    Micromachines, 12, 98 (2021).


  • Characterization of Bulk Nanobubbles Formed by Using a Porous Alumina Film with Ordered Nanopores.
    Teng Ma, Yasuo Kimura, Hideaki Yamamoto, Xingyao Feng, Ayumi Hirano-Iwata, and Michio Niwano
    The Journal of Physical Chemistry B, 124, 24, 5067-5072 (2020).
  • Capacitance extraction method for a free-standing bilayer lipid membrane formed over an aperture in a nanofabricated silicon chip.
    Yasutaka Tomioka, Shogo Takashima, Masataka Moriya, Hiroshi Shimada, Fumihiko Hirose, Ayumi Hirano-Iwata, and Yoshinao Mizugaki
    Japanese Journal of Applied Physics 59, SIIK02 (2020).
  • Establishment of a cell-free translation system from rice callus extracts.
    Kakeru Suzuki , Haruka Inoue , Satoshi Matsuoka , Ryugo Tero , Ayumi Hirano-Iwata & Yuzuru Tozawa
    Bioscience, Biotechnology, and Biochemistry (2020).
  • Self-Assembly of Hybrid Lipid Membranes Doped with Hydrophobic Organic Molecules at the Water/Air Interface.
    Xingyao Feng, Teng Ma, Daisuke Tadaki, Ayumi Hirano-Iwata
    J. Vis. Exp., e60957 (2020).
  • Suppression of hypersynchronous network activity in cultured cortical neurons using an ultrasoft silicone scaffold.
    T. Sumi, H. Yamamoto, A. Hirano-Iwata
    Soft Matter, 16, 3195-3202 (2020).
  • Advances in Artificial Cell Membrane Systems as a Platform for Reconstituting Ion Channels.
    M. Komiya, M. Kato, D. Tadaki, T. Ma, H. Yamamoto, R. Tero, Y. Tozawa, M. Niwano, A. Hirano-Iwata
    Chem. Rec., 20, 730-742 (2020).
  • Optical transport of sub-micron lipid vesicles along a nanofiber.
    T. Yoshino, D. Yamaura, M. Komiya, M. Sugawara, Y. Mitsumori, M. Niwano, A. Hirano-Iwata, K. Edamatsu, M. Sadgrove
    Optics Express 28, 38527 (2020).
  • Piezoelectric PVDF-based flexible sensors with high pressure sensitivity induced by chemical modification of electrode surfaces.
    D. Tadaki, T. Ma, S. Yamamiya, S. Matsumoto, Y. Imai, A. Hirano-Iwata, M. Niwano
    Sensors and Actuators A, 316, 112424 (2020).
  • Contribution of AMPA and NMDA receptors in the spontaneous firing patterns of single neurons in autaptic culture.
    K. Hattori, T. Hayakawa, A. Nakanishi, M. Ishida, H. Yamamoto, A. Hirano-Iwata, T. Tanii
    BioSystems., 198, 104278 (2020).
  • Polydimethylsiloxane microfluidic films for in vitro engineering of small-scale neuronal networks.
    T. Takemuro, H. Yamamoto, S. Sato, A. Hirano-Iwata
    Jpn. J. Appl. Phys., 59(11), 117001 (2020).
  • Bactericidal activity of TiO2 nanotube thin films on Si by photocatalytic generation of active oxygen species.
    M. Yamaguchi, H. Abe, T. Ma, D. Tadaki, A. Hirano-Iwata, M. Niwano
    Langmuir, 36, 12668-12677 (2020).
  • Response characteristics of a highly sensitive gas sensor using a titanium oxide nanotube film decorated with platinum nanoparticles.
    H. Abe, Y. Kimura, T. Ma, D. Tadaki, A. Hirano-Iwata, M. Niwano
    Sensors and Actuators B, 321, 128525 (2020).
  • Advances in artificial cell membrane systems as a platform for reconstituting ion channels.
    M. Komiya, M. Kato, D. Tadaki, T. Ma, H. Yamamoto, R. Tero, Y. Tozawa, M. Niwano, A. Hirano-Iwata
    Chem. Rec., 20, 1–14 (2020).
  • Printed 3D electrode arrays with micrometer - scale lateral resolution for extracellular recording of action potentials.
    L. Grob, H. Yamamoto, S. Zips, P. Rinklin, A. Hirano-Iwata, B. Wolfrum
    Adv. Mater. Technol. 5, 1900517 (2020).
  • Dielectrophoretic Assembly of Gold Nanoparticle Arrays Evaluated in Terms of Room-Temperature Resistance.
    Y. Mizugaki, M. Moribayashi, T. Yagai, M. Moriya, H. Shimada, A. Hirano-Iwata, F. Hirose
    IEICE Transactions on Electronics. E103.C(2) 62-65 (2020).
  • Modular networks of spiking neurons for applications in time-series information processing.
    S. Moriya, H. Yamamoto, A. Hirano-Iwata, S. Kubota, S. Sato
    Nonlinear Theory and Its Applications, IEICE, 11, 590-600 (2020).


  • Modulation of Photoinduced Transmembrane Currents in a Fullerene-Doped Freestanding Lipid Bilayer by a Lateral Bias.
    T. Ma, X. Feng, T. Ohori, R. Miyata, D. Tadaki, D. Yamaura, T. Deguchi, M. Komiya, K. Kanomata, F. Hirose, M. Niwano, A. Hirano-Iwata
    ACS Omega, 4, 18299-18303 (2019).
  • Formation and characterization of air-stable lipid bilayer membranes incorporated with phthalocyanine molecules.
    X. Feng, T. Ma, D. Yamaura, D. Tadaki, A. Hirano-Iwata
    J. Phys. Chem. B 123, 6515-6520 (2019).
  • Ultrasoft silicone gel as a biomimetic passivation layer in inkjet‐printed 3D MEA devices.
    H. Yamamoto, L. Grob, T. Sumi, K. Oiwa, A. Hirano-Iwata, B. Wolfrum
    Adv. Biosys. 3, 1900130 (2019).
  • 人工細胞膜とバイオセンサー
    小宮麻希, 佐藤まどか, 平野愛弓
    ファルマシア 55, 409-413 (2019).
  • Proteoliposome fusion to artificial lipid bilayer promoted by domains of polyunsaturated phosphatidylethanolamine.
    M. W. S. Goh, A. Hirano-Iwata, M. Niwano, R. Tero
    Jpn. J. Appl. Phys. 58, SIIB13 (2019).
  • Equivalent circuit model modified for free-standing bilayer lipid membranes beyond 1 TΩ.
    Y. Tomioka, S. Takashima, M. Moriya, H. Shimada, F. Hirose, A. Hirano-Iwata, Y. Mizugaki
    Jpn. J. Appl. Phys. 58, SDDK02 (2019).
  • Evaluation of the inter-particle distance of gold nanoparticles dispersed on silane-treated substrates to fabricate dithiol-connected arrays.
    T. Yagai, K. Matsumoto, M. Moribayashi, M. Moriya, H. Shimada, A. Hirano-Iwata, F. Hirose, Y. Mizugaki
    Jpn. J. Appl. Phys. 58, SDDF09 (2019).
  • Mean-field analysis of directed modular networks.
    S. Moriya, H. Yamamoto, H. Akima, A. Hirano-Iwata, S. Kubota, S. Sato
    Chaos 29, 013142 (2019).
  • Photomodulation of electrical conductivity of a PCBM-doped free-standing lipid bilayer in buffer solution.
    K. Kanomata, T. Deguchi, T. Ma, T. Haseyama, M. Miura, D. Yamaura, D. Tadaki, M. Niwano, A. Hirano-Iwata, F. Hirose
    J. Electroanal. Chem. 832, 55-58 (2019).
  • A Teflon-based system for applying multidirectional voltages to lipid bilayers as a novel platform for membrane proteins.
    M. Komiya, K. Kanomata, R. Yokota, Y. Tsuneta, M. Sato, D. Yamaura, D. Tadaki, T. Ma, H. Yamamoto, Y. Tozawa, A. Marti, J. Madrenas, S. Kubota, F. Hirose, M. Niwano, A. Hirano-Iwata
    arXiv 1907.05643 (2019).


  • Impact of modular organization on dynamical richness in cortical networks.
    H. Yamamoto, S. Moriya, K Ide, T. Hayakawa, H. Akima, S. Sato, S. Kubota, T. Tanii, M. Niwano, S. Teller, J. Soriano, A. Hirano-Iwata
    Sci. Adv. 4, eaau4914 (2018).
  • 微細加工シリコンチップに基づく人工細胞膜を用いた薬物副作用評価法.
    但木大介, 山浦大地, 馮 興堯, 平野愛弓
    生物物理 58, 324-327 (2018).
  • 人工細胞膜を用いたイオンチャネルタンパク質解析系の開発 ―個別化医療のためのhERGチャネル薬物副作用評価系を目指して―
    小宮麻希, 馬 騰, 但木大介, 平野愛弓
    分析化学 67, 749-760 (2018).
  • A single-cell based hybrid neuronal network configured by integration of cell micropatterning and dynamic patch-clamp.
    H. Yamamoto, T. Hayakawa, T. I. Netoff, A. Hirano-Iwata
    Appl. Phys. Lett. 113, 133703 (2018).
  • Dependence and homeostasis of membrane impedance on cell morphology in cultured hippocampal neurons.
    R. Matsumura, H. Yamamoto, T. Hayakawa, S. Katsurabayashi, M. Niwano, A. Hirano-Iwata
    Sci. Rep. 8, 9905 (2018).
  • Amphiphobic septa enhance the mechanical stability of free-standing bilayer lipid membranes.
    D. Yamaura, D. Tadaki, S. Araki, M. Yoshida, K. Arata, T. Ohori, K. Ishibashi, M. Kato, T. Ma, R. Miyata, H. Yamamoto, R. Tero, M. Sakuraba, T. Ogino, M. Niwano, A. Hirano-Iwata
    Langmuir 34, 5615-5622 (2018).
  • Effective subnetwork topology for synchronizing interconnected networks of coupled phase oscillators.
    H. Yamamoto, S. Kubota, F. A. Shimizu, A. Hirano-Iwata, M. Niwano
    Front. Comput. Neurosci. 12, 17 (2018).
  • Unveil the full potential of integrated-back-contact perovskite solar cells using numerical simulation.
    T. Ma, Q. Song, D. Tadaki, M. Niwano, A. Hirano-Iwata
    ACS Appl. Energy Mater. 1, 970-975 (2018).
  • Micro- and nano-fabrication methods for ion-channel reconstitution in bilayer lipid membranes.
    D. Tadaki, D. Yamaura, K. Arata, T. Ohori, T. Ma, H. Yamamoto, M. Niwano, A. Hirano-Iwata
    Jpn. J. Appl. Phys. 57, 03EA01 (2018).
  • One-dimensional array of small tunnel junctions fabricated using 30-nm-diameter gold nanoparticles placed in a 140-nm-wide resist groove.
    Y. Mizugaki, K. Matsumoto, M. Moriya, H. Shimada, A. Hirano-Iwata, F. Hirose
    Jpn. J. Appl. Phys. 57, 098006 (2018).
  • Numerical simulation of single-electron tunneling in random arrays of small tunnel junctions formed by percolation of conductive nanoparticles.
    Y. Mizugaki, H. Shimada, A. Hirano-Iwata, F. Hirose
    IEICE Trans. Electron. E101-C, 836-839 (2018).
  • In situ modification of cell-culture scaffolds by photocatalysis of visible-light-responsive TiO2 film.
    S. Kono, K. Furusawa, A. Kurotobi, K. Hattori, H. Yamamoto, A. Hirano-Iwata, T. Tanii
    Jpn. J. Appl. Phys. 57, 027001 (2018).


  • Mechanically stable solvent-free lipid bilayers in nano- and micro-tapered apertures for reconstruction of cell-free synthesized hERG channels.
    D. Tadaki, D. Yamaura, S. Araki, M. Yoshida, K. Arata, T. Ohori, K. Ishibashi, M. Kato, T. Ma, R. Miyata, Y. Tozawa, H. Yamamoto, M. Niwano, A. Hirano-Iwata
    Sci. Rep. 7, 17736 (2017).
  • Charge transport properties of bulk-heterojunction organic solar cells investigated by displacement current measurement technique.
    T. Ma, J. Zhang, D. Tadaki, Y. Kimura, A. Hirano-Iwata, M. Niwano
    Org. Electron. 51, 269-276 (2017).
  • Formation of cell membrane component domains in artificial lipid bilayer.
    R. Tero, K. Fukumoto, T. Motegi, M. Yoshida, M. Niwano & A. Hirano-Iwata
    Sci. Rep. 7, 17905 (2017).
  • Astrocytes with previous chronic exposure to amyloid β-peptide fragment 1–40 suppress excitatory synaptic transmission
    H. Kawano, K. Oyabu, H. Yamamoto, K. Eto, Y. Adaniya, K. Kubota, T. Watanabe, A. Hirano-Iwata, J. Nabekura, S. Katsurabayashi, K. Iwasaki
    J. Neurochem. 143, 624-634 (2017).
  • Fabrication of Au-nanoparticle-embedded lipid bilayer membranes supported on solid substrates.
    N. Sakaguchi, Y. Kimura, A. Hirano-Iwata, T. Ogino
    J. Phys. Chem. B. 121, 4474-4481 (2017).
  • Gate-tuned negative differential resistance observed at room temperature in an array of gold nanoparticles.
    T. T. T. Huong, K. Matsumoto, M. Moriya, H. Shimada, Y. Kimura, A. Hirano-Iwata, Y. Mizugaki
    Appl. Phys. A. 123, 268 (2017).
  • Response characteristics of hydrogen gas sensor with porous piezoelectric poly(vinylidene fluoride) film.
    Y. Imai, D. Tadaki, T. Ma, Y. Kimura, A. Hirano-Iwata, M. Niwano
    Sens. Actuators B Chem. 247, 479-489 (2017).
  • Fabrication and characterization of high-quality perovskite films with large crystal grains.
    T. Ma, Q. Zhang, D. Tadaki, A. Hirano-Iwata, M. Niwano
    J. Phys. Chem. Lett. 8, 720-726 (2017).
  • Fabrication and characterization of front-illuminated dye-sensitized solar cells with anodic titanium oxide nanotubes.
    R. Kojima, Y. Kimura, T. Ma, K. Ishibashi, D. Tadaki, R. A. Rosenberg, A. Hirano-Iwata, M. Niwano
    J. Electrochem. Soc. 164, H78-H84 (2017).


  • Live-cell, label-free identification of GABAergic and non-GABAergic neurons in primary cortical cultures using micropatterned surface.
    S. Kono, H. Yamamoto, T. Kushida, A. Hirano-Iwata, M. Niwano, T. Tanii
    PLoS ONE 11, e0160987 (2016).
  • Unidirectional signal propagation in primary neurons micropatterned at a single-cell resolution.
    H. Yamamoto, R. Matsumura, H. Takaoki, S. Katsurabayashi, A. Hirano-Iwata, M. Niwano
    Appl. Phys. Lett. 109, 043703 (2016).
  • Label-free detection of DNA molecules moving in micro-fluidic channels by infrared absorption spectroscopy.
    T. Miyoshi, K. Ishibashi, K. Miyamoto, A. Hirano-Iwata, Y. Kimura, M. Niwano
    Sens. Actuators B Chem. 238, 917-922 (2017).
  • Size-dependent regulation of synchronized activity in living neuronal networks.
    H. Yamamoto, S. Kubota, Y. Chida, M. Morita, S. Moriya, H. Akima, S. Sato, A. Hirano-Iwata, T. Tanii, M. Niwano
    Phys. Rev. E 94, 012407 (2016).
  • Reconstitution of human ion channels into solvent-free lipid bilayers enhanced by centrifugal forces.
    A. Hirano-Iwata, Y. Ishinari, M. Yoshida, S. Araki, D. Tadaki, R. Miyata, K. Ishibashi, H. Yamamoto, Y. Kimura, M. Niwano
    Biophys. J. 110, 2207-2215 (2016).
  • Fabrication and characterization of p+-i-p+ type organic thin film transistors with electrodes of highly doped polymer.
    D. Tadaki, T. Ma, J. Zhang, S. Iino, A. Hirano-Iwata, Y. Kimura, R. A. Rosenberg, M. Niwano
    J. Appl. Phys. 119, 154503 (2016).
  • Interaction of plasma-generated water cluster ions with chemically-modified Si surfaces investigated by infrared absorption spectroscopy.
    A. Hirano-Iwata, R. Matsumura, T. Ma, Y. Kimura, M. Niwano, K. Nishikawa
    AIP Advances 6, 035017 (2016).
  • 光触媒作用を用いた液中表面改質による培養神経細胞の操作.
    山本英明, 平野愛弓, 谷井孝至, 庭野道夫
    表面科学 37, 224-229 (2016).
  • Effects of interfacial chemical states on the performance of perovskite solar cells.
    T. Ma, D. Tadaki, M. Sakuraba, S. Sato, A. Hirano-Iwata, M. Niwano
    J. Mater. Chem. A 4, 4392-4397 (2016).
  • An electrically resistive sheet of glial cells for amplifying signals of neuronal extracellular recordings.
    R. Matsumura, H. Yamamoto, M. Niwano, A. Hirano-Iwata
    Appl. Phys. Lett. 108, 023701 (2016).